Bioenergetic and Proteomic Profiling of ARID1A-Deficient Ovarian Clear Cell Carcinoma under Metabolic Challenge
Harith Aswad Ismail, Kristína Danková, Trudy Janice Philips, Brittany R. Davidson, Carly A. I. Twigg, Karthik Selvaraj, Valentino Clemente, Giancarlo Curci, Beatrice Dallan, Mihir Shetty, Asumi Hoshino, Padraig D'Arcy, Francesco Nicoli, Shijia Zhu, Stefani N. Thomas, Martina Bazzaro
This study shows that ARID1A loss in ovarian clear cell carcinoma maintains increased mitochondrial respiration and bioenergetic efficiency under metabolic challenges, with specific ETC protein changes.
bioRxiv · Oct 16, 2026 · PreprintCancer Biology