Asumi Hoshino

Bioenergetic and Proteomic Profiling of ARID1A-Deficient Ovarian Clear Cell Carcinoma under Metabolic Challenge

This study shows that ARID1A loss in ovarian clear cell carcinoma maintains increased mitochondrial respiration and bioenergetic efficiency under metabolic challenges, with specific ETC protein changes.

UNC-45A Drives ATP-Independent Microtubule Destabilization via Defect Recognition and Repair Inhibition Contributing to Neurite Dystrophy

This study identifies UNC-45A as an ATP-independent microtubule severing protein that inhibits repair of defects, leading to microtubule loss and neurite dystrophy in Alzheimer's disease.

UNC-45A is Highly Expressed in the Proliferative Cells of the Mouse Genital Tract and in the Microtubule-Rich Areas of the Mouse Nervous System

The paper identifies UNC-45A expression in proliferative cells of the mouse genital tract and microtubule-rich areas of the nervous system, suggesting its potential role in ovarian cancer and neurodegeneration.