Single-cell X-chromosome inactivation analysis links biased chimerism to differential gene expression and epigenetic erosion
Robert H. Henning, Thomas Rust, Kasper Dijksterhuis, Bart J. L. Eggen, Victor Guryev
The paper introduces a computational method to analyze X-chromosome inactivation at the single-cell level using sc/snRNA-Seq data and shows its application in identifying biased inactivation and its association with gene expression and epigenetic changes.
bioRxiv · Aug 29, 2024 · PreprintBioinformatics