Bart J. L. Eggen

The paper integrates genotype, clinical, and neuropathological data from 2,553 donors to show genetic risk overlaps across brain disorders and neuropsychiatric symptoms.

The paper investigates metabolic and transcriptional changes in microglia after phagocytosis, showing these adaptations sustain their functionality and regenerative properties.

The paper identifies microglial states associated with lesion expansion and remyelination in multiple sclerosis using spatial transcriptomics on human brain tissue.

The paper introduces a computational method to analyze X-chromosome inactivation at the single-cell level using sc/snRNA-Seq data and shows its application in identifying biased inactivation and its association with gene expression and epigenetic changes.

This paper uses spatial transcriptomics to identify regional astrocyte heterogeneity in cuprizone-induced demyelination and remyelination, revealing differential gene expression patterns across brain regions.

This study shows that radiotherapy primes microglia in rats to have a heightened immune response to future inflammation, and this effect is observed in human brain tissue.

This study shows that brain regions in glioblastoma patients exhibit signs of accelerated ageing similar to Alzheimer's disease, suggesting shared mechanisms of mitochondrial and neuronal dysfunction.

This study shows that IRF5 regulates microglial myelin clearance and cholesterol metabolism after demyelination, with implications for remyelination in multiple sclerosis.

This study shows that early-life stress alters microglial transcriptome and function in mice, affecting phagocytic capacity and gene expression in adulthood.

The paper investigates how epigenetic changes in microglia influence their response to inflammatory and genotoxic stress, identifying distinct gene networks and functional phenotypes.

The paper identifies early transcriptomic changes in brain macrophages in MS tissue, linking them to lesion development and suggesting potential therapeutic targets.

The paper profiles microglia transcriptomes in AD donors and non-demented elderly using bulk and single-cell RNA sequencing, finding no significant differences in gene expression or subcluster composition.

The paper compares gene expression profiles of demyelinated white and grey matter in MS patients, finding minimal overlap and distinct glial cell signatures.

BRAIN-SAT provides an interactive platform for exploring bulk and single-cell RNA-Seq data from neuroscience studies, enabling gene expression analysis and visualization.