Victor Guryev

PUMA identifies seven distinct aging dimensions from phenotypic data, showing they predict age-related disease risk better than traditional biomedical factors.

The paper identifies stage-specific transcriptional changes in garden dormouse cerebral cortex during hibernation phases, revealing metabolic and redox adaptations and a reversal during arousal.

The paper introduces a computational method to analyze X-chromosome inactivation at the single-cell level using sc/snRNA-Seq data and shows its application in identifying biased inactivation and its association with gene expression and epigenetic changes.

The paper presents an improved rat reference genome, mRatBN7.2, which enhances genomic, transcriptomic, and proteomics data mapping and identifies millions of genetic variations across rat strains.

FastCAR corrects ambient RNA contamination in scRNA-Seq data, improving the accuracy of differential gene expression analysis by reducing false positives.

The paper investigates chromatin protein deposition bias at G-quadruplex sites, finding a reciprocal association of parental and new proteins with G4 and C4 DNA strands, respectively.

The paper analyzes polymorphic G4 sites using ancestral genomes and population data to show strand- and context-specific mutation patterns in DNA quadruplexes.

This study investigates the role of G-quadruplexes in gene expression changes in BLM-deficient cells and finds they are not a major determinant.

The paper investigates how IL-33-induced gene expression in Th2 cells depends on IL-1RL1 haplotype and asthma status, finding stronger effects in risk haplotype carriers and a correlation with pauci-granulocytic asthma.

This study presents a high-coverage whole-genome sequencing dataset of 1,171 admixed elderly Brazilians, identifying novel variants and demonstrating the utility of WGS for genomic and clinical research in underrepresented populations.

The paper uses whole genome sequencing to compare nearly isogenic WMI and WLI inbred rats, identifying genetic variants associated with depression and stress-related traits.

The paper uses Strand-seq data to correct and construct full-length chromosomes by determining scaffold order and orientation without overlapping sequences.

Sperm DNA damage leads to genomic defects in embryos through chromosome fragmentation and segregation errors.

The paper identifies pathways with increased ensemble gene noise in pneumonia and sepsis patients and shows their predictive value for mortality.

This study identifies a large number of structural variants in human genomes using multiple sequencing technologies and presents them as a gold standard for future studies.

This study identifies novel HPE genes and oligogenic inheritance patterns in holoprosencephaly by integrating clinical data with exome sequencing and gene prioritization.

This study uses Strand-seq to show that most spontaneous sister chromatid exchanges in yeast are not caused by DNA double-strand breaks.

This paper introduces an integrative phasing strategy to generate dense and accurate whole-chromosome haplotypes using Strand-seq and long-read sequencing technologies.

This study shows that epigenetic divergence between parents can cause heterosis in Arabidopsis thaliana hybrids, with specific differentially methylated regions linked to heterotic traits.