Characterization of P. falciparum dipeptidyl aminopeptidase 3 specificity reveals structural factors responsible for differences in amino acid preferences between peptide-based substrates and covalent inhibitors.
Laura E. de Vries, Mateo I. Sanchez, Katarzyna Groborz, Laurie Kuppens, Marcin Poreba, Christine Lehmann, Fang Yuan, Shirin Arastu-Kapur, Martin Horn, Michael Mares, Matthew Bogyo, Marcin Drag, Edgar Deu
The paper characterizes P. falciparum DPAP3 specificity and identifies structural factors causing differences in amino acid preferences between peptide substrates and covalent inhibitors.
bioRxiv · Aug 10, 2018 · PreprintBiochemistry