CFTR-mediated monocyte-macrophage dysfunction revealed by cystic fibrosis proband-parent comparisons
Xi Zhang, Camille M. Moore, Laura D. Harmacek, Joanne M. Domenico, Vittobai Rashika Rangaraj, Justin E. Ideozu, Jennifer R. Knapp, Kate A. Woods, Stephanie Jump, Shuang Jia, Jeremy W. Prokop, Russell Paul Bowler, Martin J. Hessner, Erwin W. Gelfand, Hara Levy
The paper compares transcriptomic profiles of CF probands and their parents to healthy controls, revealing CFTR-related immune dysfunction in both homozygous and heterozygous carriers.
JCI Insight · Mar 21, 2022Peer-reviewedGenetic & Genomic Medicine