Xi Zhang

Scaling Multiplex qPCR Primer Design to 1000-plex using the Degenerate Incomplete Multiplex Primer List Extension (DIMPLE) Algorithm

The paper introduces DIMPLE, a scalable qPCR primer design algorithm that enables 10,000+ primers in a single reaction, achieving low VAF detection and multiplex applications.

Population-specific brain charts reveal Chinese-Western differences in neurodevelopmental trajectories

The paper develops population-specific brain charts for Chinese individuals, revealing distinct neurodevelopmental patterns compared to Western populations and showing better performance in predicting brain phenotypes.

CFTR-mediated monocyte-macrophage dysfunction revealed by cystic fibrosis proband-parent comparisons

The paper compares transcriptomic profiles of CF probands and their parents to healthy controls, revealing CFTR-related immune dysfunction in both homozygous and heterozygous carriers.

Genomic profiling of circulating tumor DNA reveals genetics and residual disease in NK/T lymphoma

This study uses ctDNA analysis to identify genetic mutations and monitor residual disease in NK/T lymphoma patients, finding KMT2D mutations correlate with poor prognosis and treatment response.