Misfolded α-synuclein causes hyperactive respiration without functional deficit in live neuroblastoma cells
Cathryn L. Ugalde, Sarah Jane Annesley, Shane E. Gordon, Katelyn H. Mroczek, Matthew A. Perugini, Victoria Lawson, Paul R. Fisher, David Isaac Finkelstein, Andrew Francis Hill
The paper shows misfolded α-synuclein, generated via PMCA, binds cardiolipin and causes hyperactive mitochondrial respiration in neuroblastoma cells without functional deficits.
Disease Models & Mechanisms · Dec 17, 2019Peer-reviewedNeuroscience