Author

Sarah Jane Annesley

La Trobe UniversityORCID 0000-0002-7604-3985Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:protein structure· 1

Frequent Co-Authors

Andrew Francis HilliD· 1 shared Annaleise R. KleiniD· 1 shared Ashish SethiiD· 1 shared Cathryn L. UgaldeiD· 1 shared David Isaac FinkelsteiniD· 1 shared Jiangtao ZhouiD· 1 shared Julian RatcliffeiD· 1 shared Katelyn H. Mroczek· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperNeuroscience

Andrew Francis HillORCID

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2 papers

Recent·Most cited

Cell invasive amyloid assemblies from SARS-CoV-2 peptides can form multiple polymorphs with varying neurotoxicity

Oana Sanislav, Rina Tetaj, Metali, Julian Ratcliffe, William Phillips, Annaleise R. Klein, Ashish Sethi, Jiangtao Zhou, Raffaele Mezzenga, Sina S. Saxer, Mirren Charnley, Sarah Jane Annesley, Nicholas P. Reynolds

This study investigates how SARS-CoV-2 peptides form amyloid assemblies with varying neurotoxicity and polymorphic structures, showing that aggregation conditions influence toxicity and cellular uptake.

Nanoscale · Jan 1, 2024Peer-reviewedBiophysics

Misfolded α-synuclein causes hyperactive respiration without functional deficit in live neuroblastoma cells

Cathryn L. Ugalde, Sarah Jane Annesley, Shane E. Gordon, Katelyn H. Mroczek, Matthew A. Perugini, Victoria Lawson, Paul R. Fisher, David Isaac Finkelstein, Andrew Francis Hill

The paper shows misfolded α-synuclein, generated via PMCA, binds cardiolipin and causes hyperactive mitochondrial respiration in neuroblastoma cells without functional deficits.

Disease Models & Mechanisms · Dec 17, 2019Peer-reviewedNeuroscience