TNF Superfamily Member 14 Drives Post-Influenza Depletion of Alveolar Macrophages Enabling Secondary Pneumococcal Pneumonia
Christina Malainou, Christin Peteranderl, Maximiliano Ruben Ferrero, Ana Ivonne Vazquez‐Armendariz, Ioannis Alexopoulos, Katharina Franz, Klara Knippenberg, Julian Better, Mohammad Estiri, Cheng‐Yu Wu, Hendrik Schultheis, Judith Bushe, María‐Luisa del Rio, José-Ignacio Rodríguez-Barbosa, Klaus Pfeffer, , Susanne Herold
This study identifies TNFSF14 as a driver of alveolar macrophage depletion after influenza, increasing susceptibility to pneumococcal pneumonia, and shows targeting this pathway can reduce disease severity.
Journal of Clinical Investigation · Nov 18, 2025Peer-reviewedMolecular Biology