Hendrik Schultheis

This study maps tRNA expression dynamics across human hematopoiesis using sc-STM-seq and identifies tRNAs linked to stemness, differentiation, and cell lineages.

SC-Framework provides a unified, containerized environment for single-cell data analysis to improve reproducibility and scalability.

This study identifies TNFSF14 as a driver of alveolar macrophage depletion after influenza, increasing susceptibility to pneumococcal pneumonia, and shows targeting this pathway can reduce disease severity.

This paper introduces DENIS, a framework for de novo motif discovery from ATAC-seq footprints to identify uncharacterized transcription factor binding.

TF-COMB identifies co-occurring transcription factors and their binding grammar using ChIP-seq data and ATAC-seq footprinting.

TOBIAS enables genome-wide analysis of TF binding dynamics using ATAC-seq data, revealing complex TF interactions during zygotic genome activation in humans and mice.

The paper introduces a web-based GUI for the UROPA tool to simplify genomic region annotation for biologists and clinicians.