A large, distinct family of RNase H fold nucleases associated with numerous defense systems in prokaryotes
Yuri I. Wolf, Kanza Arshad, Kwame Kannatey-Asibu, Rachel Q Theisen, Katherine A Kitzinger, Preeti V Jain, Eugene V. Koonin, Kira S Makarova, Hannah E Ledvina
The paper identifies and characterizes a new family of prokaryotic defense proteins, WARDs, which are associated with various defense systems and provide phage resistance.
bioRxiv · Nov 4, 2026 · PreprintMicrobiology