Rewriting regulatory DNA to dissect and reprogram gene expression
Gabriella E. Martyn, Michael T. Montgomery, Hank Jones, Katherine Guo, Benjamin R. Doughty, Johannes Linder, Deepa Bisht, Fan Xia, Xiangmeng Shawn Cai, Ziwei Chen, Kelly Cochran, Kathryn A Lawrence, Glen Munson, Anusri Pampari, Charles P. Fulco, , J Engreitz
The paper introduces Variant-FlowFISH to measure the effects of DNA sequence variants on gene expression, identifies regulatory mechanisms, and benchmarks predictive models.
Cell · Jun 1, 2025Peer-reviewedGenetics