Deepa Bisht

BRG1 cooperates with PLK1 to regulate dormant origin activation during S phase.

This study identifies BRG1's role in regulating dormant replication origin activation by interacting with PLK1, showing reduced replication fork progression upon BRG1 depletion.

Expanding the DNA Motif Lexicon of the Transcriptional Regulatory Code

The paper expands the DNA motif lexicon of transcriptional regulatory code by identifying composite elements and using a deep learning model to predict their activity and impact of variants.

Rewriting regulatory DNA to dissect and reprogram gene expression

The paper introduces Variant-FlowFISH to measure the effects of DNA sequence variants on gene expression, identifies regulatory mechanisms, and benchmarks predictive models.

Multi-scale gene regulatory networks for resolving transcription factor and autoimmune variant impacts on human B cell fate dynamics

Widespread variation in molecular interactions and regulatory properties among transcription factor isoforms

The paper identifies two categories of transcription factor isoforms with distinct molecular functions and shows they contribute to gene regulatory complexity.

PICH, an ATP-dependent chromatin remodeling protein, transcriptionally co-regulates oxidative stress response.

This study shows PICH, an ATP-dependent chromatin remodeler, co-regulates oxidative stress response with Nrf2 by modulating antioxidant gene expression and interacting with H3K27ac.

Altering mammalian transcription networking with ADAADi: An inhibitor of ATP-dependent chromatin remodeling

This paper introduces ADAADi, an inhibitor of ATP-dependent chromatin remodeling, showing anti-tumor effects by altering transcriptional networks and inducing apoptosis.