Gut microbiome-dependent IL-1 signaling is a mediator of ACVR1R206H-driven heterotopic ossification
Hannah M. Herzog, Camille Fang, Lily Lam, Katherine Jin, Ariane Zamarioli, Ethan Dinh, Chhedi Lal Gupta, Aditi Sharma, Tania A. Moody, Jessica L. Pierce, Michael S Hohl, Sarah W. Takimoto, Svetlana Lyalina, Kelly Lee Wentworth, Kristie B. Yu, , Edward Chiaming Hsiao
Antibiotic disruption of the gut microbiome reduces heterotopic ossification in FOP mice via an IL-1 mediated pathway.
bioRxiv · Apr 8, 2026 · PreprintImmunology