Chromosomal Instability in Human Trophoblast Stem Cells and Placentas
Danyang Wang, Andrew Cearlock, Katherine Lane, Chongchong Xu, Ian Jan, Stephen A. McCartney, Ian A. Glass, Rajiv C. McCoy, Min Yang
This study reveals chromosomal instability as an inherent feature of trophoblast lineage, showing high prevalence of aneuploidy in human placentas and TSCs despite maintaining proliferative capacity.
Nature Communications · Apr 25, 2025Peer-reviewedDevelopmental Biology