Stephen A. McCartney

This study identifies microRNA signatures associated with spontaneous preterm birth and links them to target genes involved in immune signaling and oxidative phosphorylation.

The paper constructs a single-cell RNA-Seq atlas of the periventricular proliferative zone in late-gestation pigtail macaque fetal brain, revealing cell states similar to human fetal brain.

The paper uses an arrayed CRISPR screen to identify ZBTB10 as a regulator of human trophoblast differentiation, showing its role in fusion and hormone secretion.

The paper examines how T cell-tissue cell communication changes in human placental tissue during acute inflammation, finding that tissue-resident CD8 T cells support trophoblast homeostasis in both healthy and inflamed states.

The paper examines tissue-specific T cell adaptations in healthy and inflamed human mucosal tissues, finding that these adaptations are largely maintained during inflammation.

The paper integrates metabolomic and transcriptomic data to identify dynamic changes in placental metabolism across trimesters in human pregnancy.

The paper identifies cytokine and metabolite networks that regulate T cell fate at the human maternal-fetal interface, showing how they restrain T cells in an antigen-independent manner.

This study reveals chromosomal instability as an inherent feature of trophoblast lineage, showing high prevalence of aneuploidy in human placentas and TSCs despite maintaining proliferative capacity.