Ian A. Glass

The paper identifies a distinct B-cell lineage generated during early human lymphopoiesis that shapes antibody specificity before birth.

The paper constructs a high-resolution human pangenome structural variant resource, identifies disease-associated SVs, and demonstrates its utility in filtering variants from probands and associating SVs with traits in a large cohort.

IsoRanker uses long-read transcriptomics to prioritize non-coding variants in Mendelian conditions by detecting expression outliers, allelic imbalance, and NMD, leading to the identification of pathogenic variants in one individual.

This study investigates the molecular effects of prenatal cannabis exposure on human fetal brains, finding significant disruptions in male second trimester brains linked to neurodevelopmental disorders.

The paper uses an arrayed CRISPR screen to identify ZBTB10 as a regulator of human trophoblast differentiation, showing its role in fusion and hormone secretion.

The paper recalibrates BAP1 MAVE data for different disease phenotypes to enable accurate variant classification across related disorders.

The paper develops TRoLR, a pipeline using long-read sequencing to detect and prioritize pathogenic tandem repeat expansions in diverse populations, identifying known and novel expansions with clinical relevance.

This paper identifies cell membrane tension as a regulator of epithelial fate transitions in the lung, showing it integrates physical and signaling cues to control AT1 and AT2 cell differentiation.

This study evaluates how delayed evacuation after fetal circulation cessation affects the quality of human fetal tissue, finding reduced cell viability and RNA quality but sufficient DNA for PCR.

The paper identifies a synaptic gene program in human oligodendrocyte precursor cells (OPCs) using single-cell RNA sequencing, revealing distinct embryonic and adult subsets with synaptic-related gene expression.

This study identifies DIO3 as a regulator of photoreceptor development timing and fate stability in human retinal organoids, proposing an hourglass model for developmental progression.

This study shows that the developmental stage of hematopoietic stem cells influences leukemic transformation, lineage hierarchy, and therapy response in pediatric leukemia.

This study generates human ventral skin and amnion-like organoids by adjusting signaling and cellular composition, revealing key developmental pathways and interactions.

The paper integrates metabolomic and transcriptomic data to identify dynamic changes in placental metabolism across trimesters in human pregnancy.

The paper constructs a cellular atlas of the early postnatal human lung and identifies two distinct AT2 cell states linked to inflammatory signaling and clinical interventions.

The paper reports seven individuals with PLCG1 variants causing hearing, vision, cardiac, and immune issues, and shows these variants have gain-of-function effects in Drosophila models.

The paper identifies biallelic variants in RNU4-2 causing a recessive neurodevelopmental syndrome with distinct white matter changes, expanding the known genotypic and phenotypic spectrum of RNU4-2-related disorders.

The paper identifies genes and regulatory networks driving electrophysiological maturation of neurons in primate prefrontal cortex, with implications for autism.

The paper identifies extracellular components in the developing fetal neocortex of humans and non-human primates using multi-omics approaches.

This study investigates ZIKV infection in fetal brain tissue, identifying astrocyte immune responses and neuronal dysfunction linked to congenital Zika syndrome.

This study shows that CHPG increases differentiation of human oligodendrocyte precursor cells and upregulates mGluR5 in MS astrocytes, suggesting potential therapeutic applications.

This study reveals chromosomal instability as an inherent feature of trophoblast lineage, showing high prevalence of aneuploidy in human placentas and TSCs despite maintaining proliferative capacity.

The paper identifies a proliferative region in the fetal human retina that continues to generate neurons late in development, similar to the non-mammalian ciliary marginal zone.

Pooling Fiber-seq gDNA with concatenated MAS-Seq cDNA in one PacBio run gives phased genome, methylome, chromatin, and transcriptome, exposing four gene disruptions from one X;13 translocation.

This study creates a gene regulation map of the human fetal heart to interpret genetic variants associated with congenital heart disease and cardiac traits, identifying valvular interstitial cells as key regulators.

The paper creates a spatially-resolved atlas of the developing human lung, identifying a WNT-driven niche that regulates basal cells.

The paper identifies a novel APOE+ elastin-producing valve interstitial cell subtype and reveals the APOE-NOTCH signaling axis regulates elastogenesis during human cardiac valve remodeling.

This paper demonstrates reliable mRNA delivery via lipid nanoparticles to specific retinal cells in mice and human ocular tissues without significant inflammation.

The paper develops a spatiotemporal multi-omics platform and machine-learning tool to manufacture hPSC-derived esophageal mucosa.

This study identifies opposing roles for TGFbeta and BMP signaling in generating AT2-like cells from lung progenitors in vitro.