Genome-wide RNA binding analysis of C9orf72 poly(PR) dipeptides
Rubika Balendra, Igor Ruiz de los Mozos, Idoia Glaria, Carmelo Milioto, Hana M. Odeh, Katherine M Wilson, Agnieszka M Ule, Martina Hallegger, Laura Masino, Stephen R. Martin, Rickie Patani, James Shorter, Jernej Ule, Adrian M. Isaacs
The paper identifies genome-wide RNA binding sites of poly(PR) dipeptides and shows preferential binding to GAAGA-containing RNAs, suggesting a role in neurodegeneration.
bioRxiv · Oct 10, 2022 · PreprintNeuroscience