Laura Masino

BCAS3 regulates WIPI2b via a direct interaction in the ATG16L1-binding cleft

The paper identifies BCAS3 as a novel interactor of WIPI2b that regulates its membrane association through interaction with PtdIns3P.

Cellular context restricts a promiscuous m6A reader IDR to a single functional effector interface for mRNA decay

Yeast m6A reader Pho92 uses one helical hydrophobic interface in its disordered region to engage Caf40; a single L35A substitution halts m6A-transcript decay in meiosis.

An intrinsically disordered region mediates RNA-binding selectivity and pro-oncogenic activities of LARP6

This study identifies an intrinsically disordered region in LARP6 that restricts conformational flexibility of the La-module, enabling RNA-binding selectivity and promoting cancer cell viability and invasion.

RAD51AP1 is a versatile RAD51 modulator

This paper identifies RAD51AP1 as a versatile modulator of RAD51, revealing its role in stabilizing RAD51-ssDNA filaments and promoting strand exchange through multiple binding sites.

Salmonella effector kinase SteC is activated by host-mediated phosphorylation

This study identifies that Salmonella effector kinase SteC is activated by host-mediated phosphorylation at S379, which enhances its kinase activity and promotes actin polymerisation.

Structural basis for Fc receptor recognition of immunoglobulin M

This study uses cryo-EM to determine the structural basis of Fc receptor recognition of immunoglobulin M, identifying binding sites and explaining isotype specificity.

Genome-wide RNA binding analysis of C9orf72 poly(PR) dipeptides

The paper identifies genome-wide RNA binding sites of poly(PR) dipeptides and shows preferential binding to GAAGA-containing RNAs, suggesting a role in neurodegeneration.

Common ALS/FTD risk variants in UNC13A exacerbate its cryptic splicing and loss upon TDP-43 mislocalization

The paper shows that ALS/FTD risk variants in UNC13A increase sensitivity to TDP-43 depletion by promoting cryptic exon inclusion and protein loss.