Myositis-specific autoantibodies recognizing Mi2 also target the autoimmune regulator (AIRE) protein at a shared PHD-zinc finger
Jon Musai, Sahana Jayaraman, Katherine S. Pak, Iago Pinal‐Fernandez, Sandra Muñoz-Braceras, María Casal-Domínguez, Eric Cho, Fa’alataitaua M. Fitisemanu, Peter D. Burbelo, Mariana J. Kaplan, Blake M. Warner, Adam I. Schiffenbauer, Albert Selva-O’Callaghan, Jose César Milisenda, Lisa G. Rider, , Andrew Lee Mammen
This study identifies that anti-Mi2 autoantibodies also target AIRE at a shared PHD1 domain, disrupting NuRD complex function by interfering with nucleosome anchoring.
bioRxiv · Jan 15, 2025 · PreprintImmunology