Mariana J. Kaplan

The paper introduces SFinx, a framework for spatial functional analysis of transcriptomic data, revealing spatially varying pathway interactions in lupus nephritis.

This study identifies dysregulated U12-type splicing in lupus neutrophils, linking it to impaired Nox activity and immune dysfunction.

The paper develops a mathematical model of human neutrophil maturation using single-cell RNA-seq data, identifying key transition states and rates.

This study identifies that anti-Mi2 autoantibodies also target AIRE at a shared PHD1 domain, disrupting NuRD complex function by interfering with nucleosome anchoring.

This study identifies de novo LYN variants causing constitutive Lyn kinase activation, leading to neutrophilic vasculitis and liver fibrosis, and shows therapeutic response to Src kinase inhibitors.

This paper introduces a novel hierarchical density clustering algorithm, HAL-x, which efficiently generates multiple cluster labels for single-cell data and achieves high accuracy in classifying clinical statuses.