Scarless regeneration requires post-translational proteolytic regulation via macrophage-derived Legumain
Julia Mo, Hailey Levitz, Safiyah Ali, Subin Lee, Desmarie Sherwood, Troy Anderson, Katherine Spack, Maria Blumenkrantz, Everett Weinstein, Joanna Smeeton
This study shows that macrophage-derived Legumain protease regulates ECM dynamics and proteome processing to enable scarless regeneration.
bioRxiv · Oct 23, 2026 · PreprintCell Biology