Joanna Smeeton

This study shows that macrophage-derived Legumain protease regulates ECM dynamics and proteome processing to enable scarless regeneration.

The paper shows that muscle contraction regulates TGFβ signaling and epitenon formation during embryonic tendon development, leading to structural and functional deficits in paralyzed tendons.

This study shows that adult zebrafish can regenerate functional synovial joints after complete removal, revealing a multipotent cell source and regenerative programs.

This study shows that polyamines regulate cell fate by altering chromatin structure through interactions with histone-modifying enzymes.

This study shows adult zebrafish can regenerate jaw joint ligaments without scarring through dedifferentiation of ligamentocytes and ECM remodeling, with legumain playing a key role.

The paper integrates single-cell transcriptome and chromatin accessibility data from zebrafish cranial neural crest cells across their lifetime to identify region-specific chromatin remodeling and lineage-priming factors.