Proposed allosteric inhibitors bind to the ATP site of CK2α
Paul Brear, Darby Ball, Katherine Stott, Sheena D'Arcy, Marko Hyvonen
The paper investigates whether a series of allosteric CK2 inhibitors bind to a proposed allosteric site, finding instead that they bind the ATP pocket, with discrepancies attributed to non-specific inhibition by aggregation.
Journal of Medicinal Chemistry · Oct 29, 2020Peer-reviewedBiochemistry