Author

Paul Brear

Primary ORCID profile (0000-0002-4045-0474 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Paul BreariD1 paper · University of Cambridge

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

Audrey Crousilles· 1 shared Darby Ball· 1 shared Dimitri Y. Chirgadze· 1 shared Katherine Stott· 1 shared Marko Hyvonen· 1 shared Martin WelchiD· 1 shared Sheena D'Arcy· 1 shared Stephen K. Dolan· 1 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 12 mutual co-author links

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1 shared paperBiochemistry

Audrey Crousilles

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2 papers

Recent·Most cited

Proposed allosteric inhibitors bind to the ATP site of CK2α

Paul Brear, Darby Ball, Katherine Stott, Sheena D'Arcy, Marko Hyvonen

The paper investigates whether a series of allosteric CK2 inhibitors bind to a proposed allosteric site, finding instead that they bind the ATP pocket, with discrepancies attributed to non-specific inhibition by aggregation.

Journal of Medicinal Chemistry · Oct 29, 2020Peer-reviewedBiochemistry

Three enzymes and one substrate; regulation of flux through the glyoxylate shunt in the opportunistic pathogen, Pseudomonas aeruginosa.

Audrey Crousilles, Stephen K. Dolan, Paul Brear, Dimitri Y. Chirgadze, Martin Welch

This study investigates the regulation of carbon flux through the glyoxylate shunt in Pseudomonas aeruginosa by analyzing the structure, kinetics, and reciprocal regulation of its branchpoint enzymes.

bioRxiv · May 9, 2018 · PreprintBiochemistry