Kinase activity of histone chaperone APLF maintains steady state of centrosomes in mouse embryonic stem cells
Sruthy Manuraj Rajam, Pallavi Chinnu Varghese, Mayur Balkrishna Shirude, Khaja Mohieddin Syed, Anjali Devarajan, Kathiresan Natarajan, Debasree Dutta
This study identifies APLF as a kinase in mouse embryonic stem cells that regulates centrosome number through PLK4 phosphorylation and FHA domain ATP binding.
bioRxiv · Feb 6, 2024Biochemistry