Focused ultrasound increases gene delivery to deep brain structure following the administration of a recombinant adeno-associated virus in the cerebrospinal fluid
Rikke Hahn Kofoed, Kate Noseworthy, Kathleen Wu, Laura Marie Vecchio, Chinaza Lilian Dibia, Shuruthisai Sivadas, Sheng‐Kai Wu, Kristina Mikloska, Malik White, Bradford M. Elmer, Shyam S. Ramachandran, Christian Mueller, Kullervo Hynynen, Isabelle Aubert
This study shows focused ultrasound enhances gene delivery to deep brain structures when recombinant adeno-associated virus is administered in the cerebrospinal fluid.
bioRxiv · Feb 9, 2024 · PreprintNeuroscience