4-phenylbutyrate restored GABA uptake and reduced seizures in SLC6A1 variants-mediated disorders
Gerald Nwosu, Felicia Mermer, Carson Flamm, Sarah Poliquin, Wangzhen Shen, Kathryn Rigsby, Jing‐Qiong Kang
This study shows that 4-phenylbutyrate (PBA) improves GABA uptake and reduces seizures in SLC6A1 mutation-related disorders by enhancing wildtype GAT-1 trafficking.
bioRxiv · Dec 8, 2021 · PreprintNeuroscience