NeurosciencebioRxivPreprint
4-phenylbutyrate restored GABA uptake and reduced seizures in SLC6A1 variants-mediated disorders
Gerald Nwosu, Felicia Mermer, Carson Flamm…·Jing‐Qiong Kang
This study shows that 4-phenylbutyrate (PBA) improves GABA uptake and reduces seizures in SLC6A1 mutation-related disorders by enhancing wildtype GAT-1 trafficking.
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