Small-Molecule Inhibitors Allosterically Control Bruton's Tyrosine Kinase Assembly on the Membrane
Alexander D. Fenton, Kathryn Todd, Shweta Shree, David Yin-wei Lin, Amy Hamilton Andreotti, Jean K. Chung
This study shows that small-molecule inhibitors of Btk can control its membrane assembly through allosteric effects, independent of catalytic activity.
bioRxiv · Oct 9, 2026 · PreprintBiophysics