Author

Amy Hamilton Andreotti

Iowa State UniversityORCID 0000-0002-6952-7244Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Approach:transformer / foundation model· 1

Frequent Co-Authors

David Yin-wei LiniD· 3 shared Adi RogeliD· 1 shared Alexander D. FentoniD· 1 shared D. Bruce Fulton· 1 shared Jean K. ChungiD· 1 shared Jeffrey A. PurslowiD· 1 shared Julien RocheiD· 1 shared Kathryn Todd· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersBiochemistry

David Yin-wei LinORCID

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3 papers

Recent·Most cited

BTK dynamics and function are differentially influenced by distinct covalent inhibitor warhead chemistries.

Raji E. Joseph, Robert G. Britton, David Yin-wei Lin, Julien Roche, Jeffrey A. Purslow, D. Bruce Fulton, Poowadon Fukasem, M. Paul Gleeson, Martin J.S. Dyer, Thomas E. Wales, Amy Hamilton Andreotti

This study compares the effects of different warhead chemistries in covalent inhibitors on BTK dynamics and function, showing that 2-butynamide induces conformational heterogeneity and reduced efficacy compared to acrylamide.

bioRxiv · Oct 17, 2026 · PreprintBiochemistry

Small-Molecule Inhibitors Allosterically Control Bruton's Tyrosine Kinase Assembly on the Membrane

Alexander D. Fenton, Kathryn Todd, Shweta Shree, David Yin-wei Lin, Amy Hamilton Andreotti, Jean K. Chung

This study shows that small-molecule inhibitors of Btk can control its membrane assembly through allosteric effects, independent of catalytic activity.

bioRxiv · Oct 9, 2026 · PreprintBiophysics

Discovery of novel covalent ligands with AlphaFold3

Yoav Shamir, Ronen Gabizon, Adi Rogel, David Yin-wei Lin, Amy Hamilton Andreotti, Nir London

This study demonstrates that AlphaFold3 can effectively discover novel covalent inhibitors for kinases through virtual screening, outperforming existing methods and validating predictions with co-crystallography.

Journal of the American Chemical Society · Mar 20, 2026Peer-reviewedBiochemistry