HLA-DR MODULATION AND PD-1/PD-L2 CHECKPOINT SIGNALLING DEFINE A MECHANISTIC POTENCY AXIS FOR MESENCHYMAL STROMAL CELL IMMUNOSUPPRESSION
Mahin Nikougoftar Zarif, Katia Lefsihane, Neda Khanlarkhani, Lina Sörvik, Jan F. Talts, Katarina Le Blanc, Nadir Kadri
This study establishes a standardized potency assay for mesenchymal stromal cells by linking HLA-DR modulation and PD-1/PD-L2 signaling to their immunosuppressive activity.
bioRxiv · May 6, 2026 · PreprintImmunology