PTPRJ Drives Clonal Selection in CEBPA mutated AML
Alexandra Lubin, Catherine Hockings, Yvette Hoade, Lucy Copper, Phoebe Dace, Elizabeth Hayes, Tanvi Tambaku, Madison Hill, Amandeep Bhamra, Estere Seinkmane, Catherine Zhu, Helen Brown, Ellen Nuttall Musson, Katie-Jo Thorpe, Zhangjie Chen, , Elspeth M. Payne
This study identifies PTPRJ as a driver of clonal selection in CEBPA-mutated AML by showing its role in modulating pre-leukaemic HSC expansion in zebrafish and murine models.
bioRxiv · Jul 8, 2026 · PreprintCancer Biology