Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference
Alexandra L. Young, Razvan Valentin Marinescu, Neil P. Oxtoby, Martina Bocchetta, Keir X. X. Yong, Nicholas C. Firth, David M. Cash, David Lee Thomas, Katrina M. Dick, M. Jorge Cardoso, John Cornelis Van Swieten, Barbara Borroni, Daniela Galimberti, Mario Masellis, Maria Carmela Tartaglia, , Ronald G. Thomas
This paper introduces SuStaIn, a machine learning method that identifies disease subtypes and their temporal progression from cross-sectional data, improving prediction of diagnostic conversion in neurodegenerative diseases.
Nature Communications · Oct 9, 2018Peer-reviewedNeuroscience