Arthur W. Toga

White Matter Slow-4 fALFF as a Complementary Marker in the Multimodal Alzheimer's Disease Biomarker Landscape

This study evaluates white matter slow-4 fALFF as a biomarker for Alzheimer's disease, finding it captures unique variance in neurodegeneration markers beyond traditional imaging metrics.

Genetic architecture and biological relevance of intrinsic white matter functional activity

This study identifies genetic associations with white matter functional activity, showing heritability and links to cognition but not neuropsychiatric disorders.

Genetic architecture of the limbic white matter microstructure in aging and Alzheimer's Disease.

This study identifies genetic loci and pathways associated with limbic white matter microstructure in aging and Alzheimer's Disease using multi-cohort diffusion MRI and bulk RNA-seq data.

Predicting Autopsy-Confirmed Neuropathology across Clinical, Neuroimaging, and CSF Biomarkers using Machine Learning

The paper uses machine learning to predict autopsy-confirmed neuropathology from clinical, neuroimaging, and CSF biomarkers, finding that different modalities best predict specific pathologies.

White matter microstructure and macrostructure brain charts across the human lifespan

The paper develops normative reference charts for white matter microstructure and macrostructure across the lifespan using diffusion MRI data from 50 studies.

Network-based amyloid-beta pathology predicts subsequent cognitive decline in cognitively normal older adults

This study uses machine learning to show that integrating brain connectome data with amyloid-beta PET imaging improves prediction of cognitive decline in older adults.

Hemispheric Asymmetry of Tau Pathology is Related to Asymmetric Amyloid Deposition in Alzheimer's Disease

The paper investigates whether hemispheric asymmetry in tau pathology in Alzheimer's disease is linked to reduced inter-hemispheric connectivity or asymmetric amyloid-beta distribution, finding a strong association with amyloid-beta laterality.

Neuroimaging-AI endophenotypes reveal underlying mechanisms and genetic factors contributing to progression and development of four brain disorders

The paper identifies nine neuroimaging endophenotypes linked to genetic loci and shows they improve prediction of systemic diseases and mortality.

Alzheimer's Disease Sequencing Project Release 4 Whole Genome Sequencing Dataset

The paper provides a whole-genome sequencing dataset of 36,361 ADSP participants, including variant annotations, phenotypes, and a linkage disequilibrium panel for Alzheimer's Disease research.

Perivascular and parenchymal fluid characteristics are related to age and cognitive performance across the lifespan

This study examines age-related changes in perivascular and parenchymal fluid flow characteristics and their relationship with cognitive performance across development and aging.

The spatial organization of ascending auditory pathway microstructural maturation from infancy through adolescence using a novel fiber tracking approach

This study uses diffusion MRI to track microstructural maturation of the auditory pathway from infancy to adolescence, finding spatially varying development patterns.

The Genetic Architecture of Biological Age in Nine Human Organ Systems

This study identifies 393 genomic loci associated with biological age gaps in nine human organ systems using UK Biobank data, revealing organ-specific and pleiotropic genetic effects.

Sex, racial, and APOE-ϵ4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging and Alzheimer's disease

The paper examines how sex, race, and APOE-ε4 allele status affect white matter microstructure across multiple aging and Alzheimer's disease cohorts.

The Genetic Architecture of Multimodal Human Brain Age

This study identifies sixteen genome-wide significant loci associated with brain age gaps derived from MRI modalities and highlights potential causal relationships between brain aging and diseases.

Polygenic effects on the risk of Alzheimer's disease in the Japanese population

This paper evaluates the polygenic risk score for Alzheimer's disease in Japanese individuals, showing its utility despite genetic differences from European populations.

Spatiotemporal patterns of cortical microstructural maturation in children and adolescents with diffusion MRI

This study uses diffusion MRI to analyze spatiotemporal patterns of cortical microstructural maturation in children and adolescents, finding heterogeneous development across functional domains.

Brain perivascular space imaging across the human lifespan

The paper examines age-related changes in perivascular spaces (PVS) using MRI data from a large cohort, showing age and sex influence PVS size and distribution across the lifespan.

Preserved cognition in elderly with intact rhinal cortex

This study compares age-related volumetric changes in the medial temporal lobe between cognitively normal individuals and those with mild cognitive impairment, finding the rhinal cortex is less affected by aging and more indicative of Alzheimer's disease pathology.

Aberrant Functional Connectivity between Reward and Inhibitory Control Networks in Pre-Adolescent Binge Eating Disorder

This study identifies reduced functional connectivity between reward and inhibitory control networks in pre-adolescent children with binge eating disorder compared to controls.

Laminar perfusion imaging with zoomed arterial spin labeling at 7 Tesla

This paper introduces a 3D zoomed arterial spin labeling technique at 7T to quantitatively measure laminar cerebral blood flow in human brain regions during rest and task activation.

Tractography dissection variability: what happens when 42 groups dissect 14 white matter bundles on the same dataset?

This study evaluates variability in white matter bundle segmentation across 42 groups using the same dataset, finding protocol variability exceeds other sources of inconsistency.

Brain age predicted using graph convolutional neural network explains developmental trajectory in preterm neonates

This paper uses a graph convolutional neural network to predict brain age in preterm neonates, showing it outperforms other methods and links brain age to future neurodevelopmental outcomes.

SC-GAN: 3D self-attention conditional GAN with spectral normalization for multi-modal neuroimaging synthesis

The paper introduces SC-GAN, a 3D conditional GAN with self-attention and spectral normalization for multi-modal neuroimaging synthesis, showing improved performance over 2D and 3D baselines.

Improving brain age estimates with deep learning leads to identification of novel genetic factors associated with brain aging

This study improves brain age prediction using deep learning and identifies four genetic loci associated with brain aging, three of which are novel.

Robust T1 MRI cortical surface pipeline for neonatal brain and systematic evaluation using multi-site MRI datasets

This paper introduces a robust T1 MRI cortical surface pipeline for neonatal brains and evaluates it across multiple datasets, showing high accuracy and reproducibility.

Mapping Complex Brain Torque Components and Their Genetic and Phenomic Architecture in 24,112 healthy individuals

This study analyzes brain torque components in 24,112 individuals, finding sex/handedness differences, heritability up to 56%, and genome- and phenome-wide associations with various traits.

Tractography-Pathology Correlations in Traumatic Brain Injury: A TRACK-TBI Study

This study uses ex vivo diffusion MRI and histopathology to correlate tract disruptions with axonal injury in a TBI patient.

Quality Control Metrics for Whole Blood Transcriptome Analysis in the Parkinson's Progression Markers Initiative (PPMI)

The paper quantifies technical variability in whole blood transcriptome data from the PPMI study using pooled reference samples and describes the dataset's availability.

Stick Stippling for Joint 3D Visualization of Diffusion MRI Fiber Orientations and Density

This paper introduces a stick stippling method for visualizing diffusion MRI fiber orientations and density, improving legibility and reducing clutter through 3D tube rendering and jittering techniques.

Alteration of perivascular spaces in early cognitive decline

The paper shows that early cognitive dysfunction is associated with altered perivascular space presence and distribution, linked to tau tangle deposition in Alzheimer's disease pathology.