GPCR-targeted imaging and manipulation of homeostatic microglia in living systems
Swathi Vanaja Chandrasekharan, Payal Chaubey, Sunny Khandelwal, Raghavender Medishetti, Sushreeta Chakraborty, Shruthi Rajaram, Kavya Jayakumar, Pikaso Latua, Rythem Goyal, R Gopalakrishna, Sougat Das, Kiranam Chatti, Kalyaneswar Mandal, Aneesh Tazhe Veetil
This paper develops a molecular tool to image and manipulate homeostatic microglia in vivo by targeting P2RY12, revealing microglia-pathogen interactions and morphological states in zebrafish and mice.
bioRxiv · Apr 1, 2025 · PreprintImmunology