Kiranam Chatti

GPCR-targeted imaging and manipulation of homeostatic microglia in living systems

This paper develops a molecular tool to image and manipulate homeostatic microglia in vivo by targeting P2RY12, revealing microglia-pathogen interactions and morphological states in zebrafish and mice.

LEVERAGING TRANSFER LEARNING FOR HIGH-ACCURACY PHENOTYPIC SCREENING IN ZEBRAFISH IMAGE ANALYSIS

This paper presents a transfer learning method for classifying zebrafish images before and after drug treatment, achieving high accuracy in detecting phenotypic changes.

Impaired ovarian development in a zebrafish fmr1 knockout model

This study investigates ovarian development defects in zebrafish fmr1 knockout models, identifying three mechanisms involving neuroendocrine signaling, germ cell gene expression, and mitochondrial impairment.

An efficient and cost-effective method for directed mutagenesis at multiple dispersed sites - a case study with Omicron Spike DNA

The paper presents a cost-effective method for introducing multiple mutations into DNA, demonstrated using the Omicron Spike DNA construct.