Uncertainty-Aware Deep Learning for Multi-Metric and Dose-Specific Prediction of Drug Synergy
Muhammad Javad Heydari, Bryan Lye, Parvin Mansouri, Thomas Marsland, Kavya Pamulapati, Robert Vary, Hermione E Allen, Kaylene J Simpson, John George Lock, James McKenna, Fatemeh Vafaee
AlgoraeOS predicts drug synergy with dose-specific inhibition profiles and uncertainty estimates, achieving strong performance across diverse tissues and drug mechanisms.
bioRxiv · Nov 5, 2025 · PreprintBioinformatics