John George Lock

The paper develops a workflow for isolating and profiling adult teleost cardiac cells, revealing exercise-induced hypertrophy and hyperplasia and defining proteo-transcriptomic regulatory networks.

The paper shows that pre-existing epithelial-mesenchymal (E/M) cell states determine differential phospho-signaling responses to EGF in NSCLC cells.

AlgoraeOS predicts drug synergy with dose-specific inhibition profiles and uncertainty estimates, achieving strong performance across diverse tissues and drug mechanisms.

This paper introduces a deep multiplexed imaging technique to profile up to 50 markers per circulating tumor cell, enhancing biomarker analysis for precision oncology.

This paper introduces SemaPlex, a method that enhances multiplexed fluorescence imaging by semantically unmixing markers, enabling higher plexity and accurate cell phenotype classification.

This study shows that capillary constrictions reprogram melanoma cells to a tumorigenic cancer stem cell-like state via PIEZO1 mechanosensing.

The paper shows that image quality metrics (IQMs) are unreliable for guiding fluorescence microscopy image processing as they do not correlate with downstream biological analysis performance.

The paper identifies a selective JNK inhibitor that blocks metastasis in triple-negative breast cancer by targeting metabolic pathways.