Nutrient landscape shapes the genetic diversification of the human gut commensal Bacteroides thetaiotaomicron
Michaela Lang, Christos Zioutis, Andreas Heberlein, Nika Ivanovova, Jasmin Schwarz, Stephan Köstlbacher, Olga Bochkareva, Kayla Flanagan, Fátima C. Pereira, David Berry
This study shows that complex nutrient environments drive genetic diversification in Bacteroides thetaiotaomicron through increased SNPs and DNA inversions, leading to adaptive traits like faster glucose depletion and amylopectin degradation.
bioRxiv · Jun 24, 2025 · PreprintMicrobiology