Author

Christoph Gasché

Medical University of ViennaORCID 0000-0002-3752-6685Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Assay:metagenomics· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Michaela LangiD· 3 shared Athanasios MakristathisiD· 2 shared Bela HausmanniD· 2 shared Cornelia VeselyiD· 2 shared David BerryiD· 2 shared Fátima C. PereiraiD· 2 shared Adrian Frick· 1 shared Adrian TettiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersMicrobiology

Michaela LangORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Host-derived bile acids drive dysbiosis by selecting bile-resistant epimerizing bacteria in inflammatory bowel disease

Maximilian Baumgartner, Franziska Schnaufer, Maëva Duquesnoy, Takahiro Asatsuma, Adrija Chakrabarty, Adrian Frick, Claudia D. Fuchs-Steiner, Michael Gerstorfer, Patrik Hains, Thomas Köcher, Patrick Schimmel, Mauriz A. Lichtenstein, Sofia Leistl, Felix Pinter, Elena Krstevska, , Clarissa Campbell

The paper identifies epimerized host-derived bile acids as a driver of dysbiosis in IBD by selecting for bile-resistant bacteria that disrupt host bile acid feedback signaling.

bioRxiv · Jun 19, 2026 · PreprintMicrobiology

Genome-wide sweeps create fundamental ecological units in the human gut microbiome

Xiaoqian Annie Yu, Cameron R. Strachan, Craig William Herbold, Michaela Lang, Christoph Gasché, Athanasios Makristathis, Nicola Segata, Shaul Pollak, Adrian Tett, Martin F. Polz

The paper identifies genome-wide selective sweeps in the human gut microbiome, revealing ecologically distinct populations linked to age and colorectal cancer.

Nature · May 6, 2026Peer-reviewedMicrobiology

Edited Filamin A in myeloid cells reduces intestinal inflammation and protects from colitis

Riem Gawish, Rajagopal Varada, Florian Deckert, Anastasiya Hladik, Linda Steinbichl, Laura Cimatti, Katarina Milanovic, Mamta K Jain, Natalya Torgasheva, Andrea Tanzer A, Kim De Paepe, Tom Van de Wiele, Bela Hausmann, Michaela Lang, Martin Pechhacker, , Cornelia Vesely

This study shows that RNA editing of FLNA in myeloid cells reduces intestinal inflammation and protects against colitis in mice and humans.

bioRxiv · Mar 25, 2025 · PreprintMolecular Biology

Human-derived microRNA 21 regulates indole and L-tryptophan biosynthesis transcripts in a prominent gut symbiont

Kayla Flanagan, Kirsten Gassner, Michaela Lang, Jurgita Ozelyte, Bela Hausmann, Daniel Crepaz, Petra Pjevac, Christoph Gasché, David Berry, Cornelia Vesely, Fátima C. Pereira

This study shows that human-derived miR-21 interacts with gut microbiota and regulates bacterial transcripts involved in indole and L-tryptophan biosynthesis, potentially influencing intestinal function and disease.

mBio · Jan 29, 2025Peer-reviewedMicrobiology