Tlr4 and Nlrp3 Inflammasome Signaling Drive a Delayed Secondary Wave of Hyperexcitability After TBI in Larval Zebrafish: Implications for Post-Traumatic Epileptogenesis
Leith M.T. Alkhatib, Tanja C. Zerulla, Kayla M. Finlay, W. Ted Allison
This study identifies a delayed secondary inflammatory wave driven by Tlr4 and Nlrp3 inflammasome signaling that contributes to post-traumatic epileptogenesis in larval zebrafish, suggesting a therapeutic window for anti-inflammatory interventions.
bioRxiv · Aug 5, 2026 · PreprintNeuroscience