W. Ted Allison

Seizures and tauopathy following neurotrauma are mediated by prion protein and metabotropic glutamate receptor 5

This study investigates the role of the mGluR5-PrPC pathway in linking traumatic brain injury to seizures and tauopathy using zebrafish models.

Traumatic Brain Injury induces persistent behavioural deficits that are rescued by the antiepileptic drug Levetiracetam

This study investigates the long-term behavioral effects of traumatic brain injury (TBI) in larval zebrafish and evaluates the efficacy of levetiracetam (LEV) in mitigating these deficits.

JNJ-42153605, a mGluR2 PAM, potentiates Levetiracetam treatments of TBI to mitigate subsequent tau aggregation in a larval zebrafish model

The paper tests whether anti-epileptic drugs and mGluR2 PAMs applied after TBI can prevent tau aggregation and neurodegeneration in a zebrafish model.

Subfunctionalization of tbx2 paralogues during photoreceptor cell specification in zebrafish

The paper shows that tbx2a and tbx2b subfunctionally regulate photoreceptor cell fate in zebrafish, with tbx2b promoting sws1 cone differentiation and tbx2a involved in regeneration.

Tlr4 and Nlrp3 Inflammasome Signaling Drive a Delayed Secondary Wave of Hyperexcitability After TBI in Larval Zebrafish: Implications for Post-Traumatic Epileptogenesis

This study identifies a delayed secondary inflammatory wave driven by Tlr4 and Nlrp3 inflammasome signaling that contributes to post-traumatic epileptogenesis in larval zebrafish, suggesting a therapeutic window for anti-inflammatory interventions.

Pharmacological profiling of brain activity in zebrafish

This study develops an in vivo zebrafish screening assay to identify drugs that suppress convulsant-induced neuronal hyperexcitability, finding that Kv7 channel activators are consistently effective.

Matrix metalloproteinases proteolyze RAB proteins and contribute to cisplatin-induced ototoxicity

This study shows MMP-2 and MMP-9 contribute to cisplatin-induced ototoxicity by cleaving RAB proteins, and inhibiting them improves hair cell survival.

A larval zebrafish model of TBI: Optimizing the dose of neurotrauma for discovery of treatments and aetiology

This paper develops a larval zebrafish model of TBI to optimize injury severity for studying treatment and aetiology, observing correlations between injury levels and clinical phenotypes like seizures and tau aggregation.

Seizures are a druggable mechanistic link between TBI and subsequent tauopathy

This study shows that post-traumatic seizures and dynamin-dependent endocytosis promote tauopathy spread after TBI using a zebrafish model.

Nrl is dispensable for specification of rod photoreceptors in adult zebrafish contrasting a deeply conserved requirement earlier in ontogeny

The paper shows that Nrl is necessary for rod photoreceptor specification in zebrafish larvae but dispensable in adults, suggesting a non-canonical pathway for rod development in adults.

Sleep is bi-directionally modified by amyloid beta oligomers

This study shows that amyloid beta oligomers can either enhance or suppress sleep in zebrafish depending on their length, with distinct molecular mechanisms involved.

A bright and high-performance genetically encoded Ca2+ indicator based on mNeonGreen fluorescent protein

The paper develops a new genetically encoded Ca2+ indicator, mNG-GECO1, based on mNeonGreen, which is brighter than GCaMP6s and performs comparably in various imaging applications.

In Silico Determined Properties of Designed Superoxide Dismutase-1 Mutants Predict ALS-like Phenotypes In Vitro and In Vivo

The paper designs and tests SOD1 mutants using computational methods, showing that a destabilizing mutant causes ALS-like phenotypes while a stabilizing mutant rescues them in zebrafish.