The Hsp40 co-chaperone DNAJC7 regulates polyglutamine aggregation and exhibits context-dependent effects on polyglycine aggregation
Biswarathan Ramani, Kean Ehsani, Martin Kampmann
This study develops cell-based models to evaluate genetic modifiers of polyQ and polyG aggregation, identifying DNAJC7 as a suppressor of polyQ aggregation but not polyG.
Journal of Biological Chemistry · Feb 17, 2026Peer-reviewedNeuroscience