Biswarathan Ramani

The Hsp40 co-chaperone DNAJC7 regulates polyglutamine aggregation and exhibits context-dependent effects on polyglycine aggregation

This study develops cell-based models to evaluate genetic modifiers of polyQ and polyG aggregation, identifying DNAJC7 as a suppressor of polyQ aggregation but not polyG.

In vivo Proximity & Spatial Proteomics with CRISPR Screening Identify STXBP1 as a Protective Modifier of a-synuclein Toxicity in Dopamine Neurons.

The paper uses in vivo proteomics and CRISPR screening to identify STXBP1 as a protective factor against α-synuclein toxicity in dopamine neurons in Parkinson's disease models.

CRISPR screening by AAV episome-sequencing (CrAAVe-seq) is a highly scalable cell type-specific in vivo screening platform

The paper introduces CrAAVe-seq, an AAV-based CRISPR screening platform for in vivo cell type-specific analysis, demonstrating its scalability and sensitivity in identifying neuron-essential genes.