Metabolic adaptation to maternal hyperglycemia via ACLY-dependent acetyl-CoA production drives epigenetic remodeling and dysregulated placental development
Mengying Liu, Keer Jin, Shihong Qi, Dandan Chen, Yichen Han, Weina Xu, Caihe Wen, Haiyan Wen, Yuanwei Liu, B H He, Xiaona Lin
The paper identifies ACLY-dependent acetyl-CoA production as a mechanism linking maternal hyperglycemia to epigenetic remodeling and placental underdevelopment in gestational diabetes.
bioRxiv · Mar 20, 2026 · PreprintDevelopmental Biology