Multi-omics analyses of MEN1 missense mutations identify disruption of menin-MLL and menin-JunD interactions as critical requirements for molecular pathogenicity
Koen M.A. Dreijerink, Ezgi Ozyerli‐Goknar, Stefanie Koidl, Ewoud J. van der Lelij, Priscilla van den Heuvel, Jeffrey J. Kooijman, Martin Lothar Biniossek, Kees W. Rodenburg, Sheikh Nizamuddin, H. T. Marc Timmers
The paper identifies MEN1 missense mutations that disrupt menin-MLL and menin-JunD interactions, highlighting their role in pathogenicity.
Epigenetics & Chromatin · Aug 8, 2022Peer-reviewedMolecular Biology