H. T. Marc Timmers

This study shows that KMT2D mutations in colorectal cancer are linked to increased immune activity and better response to immunotherapy and cisplatin.

This study shows that SMAD4 MH2 mutations in colorectal cancer impair CREBBP/EP300 recruitment and TGF-β-induced transcription, explaining their loss-of-function effects.

The paper identifies socially regulated genes in ants that show increased 3D chromatin contacts with enhancers, suggesting pre-existing connectivity supports brain plasticity during caste transition.

The paper genomically rewrote a mouse Taf1 allele with a human XDP patient-derived TAF1 allele, revealing that intronic SVA retrotransposons reduce TAF1 levels and cause neurodegeneration.

This study shows that ATAC and SAGA coactivator complexes assemble co-translationally in the cytoplasm, but their localization and functions differ.

The paper shows TFIID biogenesis occurs co-translationally through hierarchical assembly driven by TAF1.

The paper identifies EOMES-induced chromatin accessibility as a key step in initiating mesendoderm lineage commitment during mammalian gastrulation.

The paper identifies MEN1 missense mutations that disrupt menin-MLL and menin-JunD interactions, highlighting their role in pathogenicity.

The paper shows that mammalian nuclear transcription complexes assemble co-translationally, with dimerization domains dictating the assembly pathway.

This study identifies the causal mechanism of X-linked Dystonia-Parkinsonism (XDP) by integrating genome and transcriptome assembly, revealing a SVA insertion causing intron retention and TAF1 dysfunction.